1. Free radical oxidation in rats in the delayed period after combined exposure to dust and radiation.
- Author
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Tapbergenov SO, Zhetpisbaev BA, Ilderbayev OZ, Zhetpisbaeva HS, Olzhayeva RR, Prozor II, Usenova OA, and Ilderbayeva GO
- Subjects
- Adaptation, Physiological, Adrenal Glands metabolism, Adrenal Glands radiation effects, Animals, Animals, Outbred Strains, Disease Models, Animal, Dust, Humans, Lipid Peroxidation, Liver metabolism, Liver radiation effects, Lymph Nodes metabolism, Lymph Nodes radiation effects, Male, Malondialdehyde metabolism, Organ Specificity, Oxidation-Reduction, Oxidative Stress, Rats, Spleen metabolism, Spleen radiation effects, Thymus Gland metabolism, Thymus Gland radiation effects, Asbestos toxicity, Carcinogens toxicity, Free Radicals metabolism, Occupational Exposure, Radioactive Pollutants toxicity
- Abstract
We studied the intensity of free radical processes in organs (liver, spleen, thymus, lymph nodes of the small intestine, and adrenal glands) and cells (lymphocytes) in the delayed period after combined exposure to a sublethal dose of γ-radiation (6 Gy) and asbestos dust particles. Combined exposure was followed by accumulation of LPO metabolites (diene conjugates and malonic dialdehyde) in homogenates of the studied organs and resulted in antioxidant defense failure in experimental animals. Ionizing radiation have a pivotal role in these processes.
- Published
- 2013
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